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Particle size distribution (Granulometry), Solubility in organic solvents / fat solubility, Stability in organic solvents and identity of relevant degradation products, Storage stability and reactivity towards container material, Biodegradation in water and sediment: simulation tests, Additional information on environmental fate and behaviour, Short-term toxicity to aquatic invertebrates, Long-term toxicity to aquatic invertebrates, Toxicity to aquatic algae and cyanobacteria, Toxicity to aquatic plants other than algae, Endocrine disrupter testing in aquatic vertebrates – in vivo, Toxicity to soil macroorganisms except arthropods, Endocrine disrupter mammalian screening – in vivo (level 3), Direct observations: clinical cases, poisoning incidents and other, Exposure related observations in humans: other data, Justification for classification or non-classification, Additional physico-chemical properties of nanomaterials, Toxicokinetics, metabolism and distribution. The duration of the exposure was 72 hours. ECA polymerizes rapidly in presence of moisture. Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). Based on this study, ethyl 2-cyanoacrylate is considered eye irritating and classified as Eye Irrit. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Hence, this document focuses on exposures via … Executive summary: In an acute dermal study similar to OECD TG 402, a limit dose of 2000 mg/kg bw ethyl 2 -cyanoacrylate was administered once on the dorsal free clipped skin of … Due to the toxicity issues of ethyl cyanoacrylate, the use of 2-octyl cyanoacrylate for sutures is preferred. Correspondingly, it is classified as STOT SE 3, H335. Based on the high structural and physicochemical similarity to ethyl 2-cyanoacrylate (ECA) and in view of the overall irritating properties of ECA, it is considered that ECA also exerts respiratory irritation. H319 Causes serious eye irritation. About the Chemical. The duration of the exposure was 24 hours. Correspondingly, it is classified as STOT SE 3, H335. 13 In attempts to decrease adhesive toxicity, new compounds were developed, replacing methyl by ethyl, butyl, or octyl, to obtain more favorable biological behavior. The skin was examined directly after the 24 -hour exposure and 72 hours after patch removal. It is soluble in acetone, methyl ethyl ketone, nitromethane, and methylene chloride. It is the main component of cyanoacrylate glues and can be encountered under many trade names. Ethyl Cyanoacrylate is an ester. Cyanoacrylate poisoning occurs when someone swallows this substance or gets it on their skin. Hence, ethyl 2-cyanoacrylate is not considered to be skin irritating. H315. A Diabetic's Allergy: Ethyl Cyanoacrylate in Glucose Sensor Adhesive. you can use a cotton swab and a light amount of product to remove bandage adhesive from skin. Some cyanoacrylate glues may lose adhesive strength with time. Learn more | Legal Disclaimer, Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Synonyms. Future exposure can cause asthma attacks with Structure, properties, spectra, suppliers and links for: Ethyl cyanoacrylate, 7085-85-0. 2-Octyl cyanoacrylate glue provides a wound closure that is similar to closure with an interrupted subcuticular absorbable suture. Cyanoacrylate adhesives offer much enhanced toughness by the inclusion of elastomeric materials capable of undergoing phase separation on curing. The aim of this study was to investigate possible reversible or irreversible irritancy by the test substance following a single application into the eyes of rabbits. Medical grade cyanoacrylate topical skin adhesive is used effectively for closing wounds, termed liquid bandaging. Ethyl cyanoacrylate, a cyanoacrylate ester, is an ethyl ester of 2-cyano-2-propenoic acid. Furthermore, evidence for respiratory irritation induced by methyl 2-cyanoacrylate exists from a study with human volunteers, and it is feasible to assign similar properties to ECA. If you’ve bonded your fingers, soak in warm soapy water and gently roll them together (as if you were rolling a pencil between your fingers). This website uses cookies to ensure you get the best experience on our websites. 2012. EC number: 230-391-5 | CAS number: 7085-85-0. Harry Coover said in 1966 that a cyanoacrylate spray was used in the Vietnam War to reduce bleeding in wounded soldiers until they could be taken to a hospital. Skin glue failed because of disruption of the skin-glue interface. 1989). Thermally resistant ethyl cyanoacrylate adhesives. The primary dermal irritation index (PDII) was found to be 0.87 (includes scores for intact and abraded skin). ethyl cyanoacrylate and polymerized ethyl cyanoacryl-ate. Methods and investigations were performed were similar to the procedure described in the OECD Guideline 404. This information has not been reviewed or verified by the Agency or any other authority. The duration of the exposure was 72 hours. Close Find out more on how we use cookies. WARNING: Avoid using acetone to clean cyanoacrylate adhesive that is stuck to plastic. These patients were challenged with a novel method of use testing to confirm sensitivity to 2-octyl cyanoacrylate. An amount of 0.5 g ethyl-2-cyanoacrylate was applied to intact skin areas and to abraded skin areas (covered with an gauze bandage) of each of 6 rabbits. 2008. The small amount of moisture in air is enough to initiate polymerization. Canadian Environmental Protection Act (CEPA) Environmental Registry. Substance has to be 0.87 ( includes scores for intact and abraded skin ) isolating all contaminated.. 8212 ; Occupational exposure to Hazardous Agents test,0.1 mL ethyl 2-cyanoacrylate ensure get... If necessary, apply a small amount of moisture in air is to... Has been used for gluing glass, ceramics and other hard materials an. 558 -561 ) gets it on their skin Chemicals Bureau ) treated rabbit eyes were after! 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